Endocrinopathies can cause various changes in coagulation and fibrinolytic mechanisms. Glucocorticoids show particulary important influence on hemostasis. Increased tendency to thromboembolic incidents is observed in either endogenous hypercortisolism or glucocorticoids administration. The aim of this paper was to present the hemostatic disturbances in patients with hypercortisolism, with particular emphasis in their development on metabolic changes, endothelium damage, influence of pro-inflammatory cytokines and hiperhomocysteinemia. The problem of anticoagulant prophylaxis in this group of patients is also discussed.