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[Central precocious puberty].

Authors: Robert, Krysiak; Bogdan, Marek; Bogusław, Okopień;

[Central precocious puberty].

Abstract

Central precocious puberty, defined as the onset of puberty before the age 8 years in girls and 9 years in boys, results from a premature activation of gonadotropin-releasing hormone neurons in the hypothalamus. This condition is characterised by early pubertal changes, acceleration of growth velocity, and rapid bone maturation that often result in reduced adult height. It may be either idiopathic or associated with hypothalamic hamartoma, brain neoplasms, numerous non-cancerous disorders of the central nervous system and treatment of peripheral precocious puberty. The goal of the initial assessment of children is to exclude the presence of all these organic disorders. The diagnosis should include detailed anamnesis and clinical examination, measurement of pituitary and sex hormones, assessment of bone age, and imaging of the hypothalamus, pituitary gland, abdomen, pelvis and gonads. The treatment of choice are gonadotropin-releasing hormone agonists. In this paper, we review the current views on the etiopathogenesis, clinical presentation, diagnosis and management of central precocious puberty.

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Keywords

Gonadotropin-Releasing Hormone, Male, Brain Diseases, Metabolic, Hypothalamus, Humans, Puberty, Precocious, Female, Child

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    popularity
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3
Average
Average
Average
gold
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