[The latest TH17 lymphocyte in the family of T CD4+ lymphocytes].

Name: [The latest TH17 lymphocyte in the family of T CD4+ lymphocytes].
Keywords: Graft Rejection, Inflammation, Antigen Presentation, Interleukins, Interleukin-17, Cell Differentiation, Th1 Cells, Lymphocyte Activation, Interleukin-22, T-Lymphocytes, Regulatory

M, Essakalli; C, Brick; N, Bennani; N, Benseffaj; S, Ouadghiri; O, Atouf

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Article . 2011

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[The latest TH17 lymphocyte in the family of T CD4+ lymphocytes].

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2011 French Journal:Pathologie-biologie, volume 58 (issn: 1768-3114,

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Authors: M, Essakalli; C, Brick; N, Bennani; N, Benseffaj; S, Ouadghiri; O, Atouf;

pmid: 19299092

[The latest TH17 lymphocyte in the family of T CD4+ lymphocytes].

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Abstract

In recent years the T CD4+ lymphocyte family has grown. In the initial two components TH1 and TH2 lymphocytes were added the TH17 lymphocyte and T cell regulator (Treg). Under the influence of transforming growth factor β, interleukin 6 (IL6), IL21 and IL23, the naive lymphocyte T CD4+ differentiates in TH17. Currently, the TH17 is recognized as the leading actor of local inflammation through the pro-inflammatory cytokines (interleukins 17, 21, 22) that secretes and the expansion and recruitment of neutrophils that leads. Therefore, it is involved in chronic inflammatory processes, autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus), allergy and rejection of allogeneic transplants. TH17 lymphocyte opens up new therapeutic prospects for these pathologies.

Keywords

Graft Rejection, Inflammation, Antigen Presentation, Interleukins, Interleukin-17, Cell Differentiation, Th1 Cells, Lymphocyte Activation, Interleukin-22, T-Lymphocytes, Regulatory, Epithelium, Autoimmune Diseases, Interleukin-21, Th2 Cells, Cell Movement, T-Lymphocyte Subsets, Hypersensitivity, Humans, Th17 Cells, Signal Transduction

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