IL-17-producing gammadelta T cells.
Copyright policy )IL-17-producing gammadelta T cells.
IL-17 is produced not only by CD4(+) alphabeta T cells, but also CD8(+) alphabeta T cells, NKT cells, and gammadelta T cells, plus some non-T cells, including macrophages and neutrophils. The ability of IL-17 to deploy neutrophils to sites of inflammation imparts this cytokine with a key role in diseases of several types. Surprisingly, gammadelta T cells are responsible for much of the IL-17 produced in several disease models, particularly early on.
- University of Colorado Denver United States
- National Jewish Health United States
Inflammation, Bacteria, Receptors, Antigen, T-Cell, alpha-beta, Interleukin-17, Receptors, Antigen, T-Cell, gamma-delta, Bacterial Infections, Autoimmune Diseases, Disease Models, Animal, Mice, T-Lymphocyte Subsets, Hypersensitivity, Animals, Cytokines, Humans
Inflammation, Bacteria, Receptors, Antigen, T-Cell, alpha-beta, Interleukin-17, Receptors, Antigen, T-Cell, gamma-delta, Bacterial Infections, Autoimmune Diseases, Disease Models, Animal, Mice, T-Lymphocyte Subsets, Hypersensitivity, Animals, Cytokines, Humans
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