[Membranotropic action of cardiotonic agents and ubiquinone].
Copyright policy )[Membranotropic action of cardiotonic agents and ubiquinone].
Interaction of cardiotonic drugs (strophantidine acetate, suphan, para-oxybenzoic acid) and ubiquinone with phospholipid bilayers has been studied. Exothermic effect of the reaction followed by an increase in microviscosity and hydrophobicity of the bilayer from cardiolipin, but by a decrease of the microviscosity of the bilayer from lecithin has been estimated. A correlation is observed between changes in the lecithin bilayer fluidity and the heat effect of the interaction at the initial period of time after mixing of reagents.
Cardiotonic Agents, Spectrometry, Fluorescence, Ubiquinone, Cell Membrane, Lipid Bilayers, Animals, Rabbits, Mitochondria, Heart, Phospholipids
Cardiotonic Agents, Spectrometry, Fluorescence, Ubiquinone, Cell Membrane, Lipid Bilayers, Animals, Rabbits, Mitochondria, Heart, Phospholipids
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