To review researches of BMSCs in tumor therapy.The recent relevant literature was extensively reviewed. The tropism of BMSCs to cancer, the effect of BMSCs on tumor growth and the application of BMSCs in tumor therapy were summarized.BMSCs has the tropism to tumor and may inhibit or enhance growth of tumor. BMSCs as gene-delivery vehicle for gene therapy had obtained certain therapeutic efficacy. However, BMSCs can become tumorigenic.BMSCs is a good gene-delivery vehicle for gene therapy. The relationship of BMSCs and tumor cells should be studied deeply for enhance the safety of BMSCs in gene therapy of tumor.