[Dendritic cells transfected with recombinant adenovirus Ad5F35-LMP2 induces LMP2 specific immunity mediated by cytotoxic T lymphocytes in vitro].

Wu-Ning, Mo; Ling, Zhou; Zhan, Wang; An-Zhou, Tang; Guang-Wu, Huang; Yi, Zeng

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Article . 2009

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[Dendritic cells transfected with recombinant adenovirus Ad5F35-LMP2 induces LMP2 specific immunity mediated by cytotoxic T lymphocytes in vitro].

descriptionPublicationkeyboard_double_arrow_right Article 14 Apr 2009Journal:Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, volume 22 (issn: 1003-9279,

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Authors: Wu-Ning, Mo; Ling, Zhou; Zhan, Wang; An-Zhou, Tang; Guang-Wu, Huang; Yi, Zeng;

pmid: 19105335

[Dendritic cells transfected with recombinant adenovirus Ad5F35-LMP2 induces LMP2 specific immunity mediated by cytotoxic T lymphocytes in vitro].

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Abstract

To observe whether dendritic cells (DCs) transfected with recombinant adenovirus Ad5F35-LMP2 induces LMP2 specific immunity mediated by cytotoxic T lymphocytes in vitro.Dendritic cells have been generated in vitro, and cocultured with autologous T cell after the DCs were infected with Ad5F35-LMP2, then the proliferation of the induced T cells and their cytotoxic activity against CNE-2 tumor cells which express EBV-LMP2 protein on membrane were assessed by MTT method.The dendritic cells could be transfected with Ad5F35-LMP2 and the CTL activated by Ad5F35-LMP2-DC could effectively suppress the proliferation of CNE-2 cells compared with control groups.The dendritic cells transfected with recombinant adenovirus Ad5F35-LMP2 showed cytotoxicity effect by activating T lymphocytes.

Related Organizations

Guangxi Medical University
China (People's Republic of)

Keywords

Viral Matrix Proteins, Epstein-Barr Virus Infections, Immunity, Cellular, Cell Line, Tumor, Genetic Vectors, Humans, Dendritic Cells, Cells, Cultured, Adenoviridae, T-Lymphocytes, Cytotoxic

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