The possibility of pneumosuit use constructed in the Institute to protect the pathology department staff at the hospitals for infectious diseases from HIV virus was studied. The suit is a hose-type suit for protection of respiratory organs and skin using the ventilated underhood space and autonomic air supply. Both the detailed description of this suit and its disinfection scheme developed and tested by authors are presented. The comparative physio-hygienic assessment of pneumosuit and standard antiplaque suit demonstrated a number of advantages of the former during 2 hours work at pathology department. The authors recommend the pneumosuit as an equipment for the protection of skin and respiratory organs of pathologists and legal physicians working with particularly dangerous infections.