Progress in neurobiological research has influenced our view of human beings and the basics of their behavior. Regarding criminal law and forensic psychiatry, established codes of practice are being challenged by neuroscientific research. This article gives an overview of neurobiological findings and methods in the context of forensic psychiatric issues. Empirical approaches to addressing important legal questions are outlined. Principles behind forensic psychiatric expert opinions are given. The effect and future of neuroscientific findings and methods in answering forensic psychiatric questions are discussed. Limitations and legal and ethical requirements are addressed.