Based on long term (1960-1990) surveillance data analysis of the plague natural foci activity on the territory of Georgia hypothetical parameters of epizootic activity algorithm have been revealed and potential role for susceptibility of noncultivated forms in the ecology of plague has been suggested. The article emphasizes the importance of circumstances, when reversal of noncultivated forms of Y. pestis creates real opportunity of microfoci development, however lack of appropriate density of rodent's population and index of abundance limit this process and do not allow initiation of epizootic processes. It is suggested that in case of surveillance of the plague foci, along with another factors more attention should be paid to identification of "additional" reservoirs and vectors, and also determine conditions, under such, they could be connected to epizootic processes. Significance of the study of influence Mingenchaury reservoir on the ecology of plain- foothill foci of plague has been also pointed out. Special attention is devoted to the fact that now when global scale of terrorism is taking place; it becomes extremely important to work toward the ensuring of biosecurity. A possibility of using biological weapons not only for bioterrorism but also for biodiversity, without much publicity for responsibility for the completed action, has been also discussed. In this case selected infectious agent is usually not exotic for the given country or region. Considering all stated above, it is becoming clear, that it is important to have strong monitoring on the natural foci of plague and detailed molecular-biological passportisation of Y. pestis strains circulating in these foci.