We assessed vegetative status and parameters of endothelial function in 53 patients with postinfarction cardiosclerosis. Balance of autonomic nervous system was characterized by the Kerdo index and heart rate variability at Holter monitoring, endothelial function - by quantity of desquamated endotheliocytes in blood and vasomotor function in test with reactive hyperemia. Patients with higher class of angina and sympatheticotonia had pronounced disturbance of endothelial function appearing as increase in number of circulating desquamated endotheliocytes and diminished sensitivity of brachial artery endothelium to shear stress.