The authors submit a report on the present state of development of tissue glues and their use in medicine. They characterize synthetic glues and the fibrin gluing system. They draw attention to the advantages and shortcomings of both systems. The composition of the fibrin glue is analyzed and its properties are analyzed, incl. the relation to treated tissue. Attention is drawn to the favourable properties of fibrin tissue glue in the treatment of tissues, the authors evaluate its sole use as well as its use in combination with traditional suture. They also mention preparations used in the production of the glue and compare the costs of their preparation. Principles for the production of the two components and prerequisites of their wider use in future are emphasized.