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Bulletin of Experime...arrow_drop_down

Bulletin of Experimental Biology and Medicine

Article . 1991

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[Combined action of anti-arrhythmia agents].

Name: [Combined action of anti-arrhythmia agents].
Keywords: Dogs, Trimecaine, Verapamil, Prajmaline, Animals, Arrhythmias, Cardiac, Drug Therapy, Combination, Anti-Arrhythmia Agents, Propranolol, Quinidine

descriptionPublicationkeyboard_double_arrow_right Article 18 Oct 1991 Russian Journal:Biulleten' eksperimental'noi biologii i meditsiny, volume 111 (issn: 0365-9615,

Authors: E I, Gendenshteĭn; Ia V, Kostin; V P, Balashov; V E, Oleĭnikov;

pmid: 1893190

[Combined action of anti-arrhythmia agents].

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Abstract

A significant potentiation of antiarrhythmic effect was observed in 121 dogs with arrhythmias 24 and 48 hours after the coronary artery ligation when the following drugs were combined: N-propylajmaline bromide (1A class) and trimecaine (1B class), quinidine (1A class) and trimecaine, N-propylajmaline bromide and anaprilin (2 class). The potentiation is attributed to the different molecular mechanisms of action of the drugs.

Keywords

Dogs, Trimecaine, Verapamil, Prajmaline, Animals, Arrhythmias, Cardiac, Drug Therapy, Combination, Anti-Arrhythmia Agents, Propranolol, Quinidine

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