Normal and irradiated fibrinogen, gamma-globulins, alpha- and beta-globulins and albumins of blood plasma were shown to contain squalene, lathosterol, cholesterol and some other compounds as lipid components. Radiation alteration of the total number of unsaponifiable substances and some lipid components in the individual blood plasma proteins followed certain regularities depending on the kind of a protein. The level of radiation changes in the content of lipid components in specific proteins of blood plasma was shown to be a function of radiation dose and time after irradiation.