Interventional cardiology has dramatically developed since its introduction in 1977. Angioplasty represents the first choice for coronary reperfusion during acute myocardial infarction with thromboaspiration and stenting of the culprit lesion. In acute coronary syndroms and stable angina or silent ischemia despite optimal medical treatment, angioplasty is today an excellent option for coronary revascularization which includes a technologic offer adapted to various clinical and anatomical situations (specific guidewires, rotative atherectomy, distal protection devices and drug eluting stents that reduce the risk of coronary reintervention after initial angioplasty). For patient with severe ischemic left ventricular dysfunction, interventional rythmology can improve patient prognosis by a limitation of lethal ventricular fibrillation. Despite the hope that intracoronary cell transplantation could save myocardial cells, several randomized control trials have given various and disappointing results concerning the potential improvement of left ventricular function. Interventional cardiology nowadays offers global technical solutions for more and more patients suffering from ischemic cardiomyopathy.