Spondylodiscitis is the most common complication of sepsis or local infection, usually of an abscess. Very often it develops in patients immunocompromised by a malignant disease, infection, or during immunosupression for organ transplantations etc. Presently, the basic diagnostic examinations to establish spondylodiscitis are the magnetic resonance (MRI) and biopsy, with microbiological tests. Lately, infection causes are increasingly proven by PCR method. In this paper we describe the causes of spondylodiscitis by reviewing the existing literature. The main causative organisms are staphylococci and Mycobacterium tuberculosis. The causes of spondylodiscitis are assigned to a large number of bacteria, fungi, zoonoses, which is to be taken into consideration in diagnostic treatment of patients (Ref. 51). Full Text (Free, PDF) www.bmj.sk.