[Comparative evaluation of 2 schedules of administration of anti- neoplastic drugs by the CMF protocol in disseminated breast cancer].
Copyright policy [Comparative evaluation of 2 schedules of administration of anti- neoplastic drugs by the CMF protocol in disseminated breast cancer].
Combined chemotherapy with cyclophosphamide, methotrexate, fluorouracil (CMF) in two regimens of administration was comparatively assessed in a randomized and prospective trial. Group I patients (n = 34) received methotrexate and fluorouracil once a week and cyclophosphamide every other day for 15 days. In group II (n = 32) all the drugs were given simultaneously once weekly for 15 days. A complete and partial response occurred significantly more frequently in patients of group I (36%) versus group II (7%). The intergroup difference in toxicity appeared insignificant.
Methotrexate, Antineoplastic Combined Chemotherapy Protocols, Liver Neoplasms, Remission Induction, Humans, Bone Neoplasms, Breast Neoplasms, Female, Fluorouracil, Prospective Studies, Cisplatin, Drug Administration Schedule
Methotrexate, Antineoplastic Combined Chemotherapy Protocols, Liver Neoplasms, Remission Induction, Humans, Bone Neoplasms, Breast Neoplasms, Female, Fluorouracil, Prospective Studies, Cisplatin, Drug Administration Schedule
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