Apoptosis in the trabecular meshwork of glaucomatous patients.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2008 Spain English Publisher:Molecular VisionJournal:Molecular vision, volume 14 (issn: 1090-0535,

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Authors: Baleriola, Jimena; García-Feijóo, Julián; Martínez de la Casa, José M.; Fernández-Cruz, Arturo; De la Rosa, Enrique J.; Fernández-Durango, Raquel;

pmid: 18728789

pmc: PMC2518170

handle: 10261/59062

Apoptosis in the trabecular meshwork of glaucomatous patients.

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Abstract

We established and validated an in toto method to perform TdT-mediated dUTP nick end labeling to study apoptosis in human trabecular meshwork tissue obtained during trabeculectomy in glaucoma patients. In specimens from patients with primary open-angle glaucoma and primary angle-closure glaucoma, we detected a tendency for more apoptotic cells to accumulate in patients with primary open-angle glaucoma. The utility of this method to study apoptosis in the trabecular meshwork is discussed, as well as its application as a tool in biologic samples

This work was supported by the Ministerio de Sanidad y Consumo (FIS 04/0251 to R.F-D.) and the Ministerio de Educación y Ciencia (SAF2007–66175 to E.J.dl.R.)

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Spain

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Keywords

Aged, 80 and over, Trabecular Meshwork, In Situ Nick-End Labeling, Humans, Apoptosis, Middle Aged, Glaucoma, Angle-Closure, Glaucoma, Open-Angle, Aged

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