AL-108 and AL-208, formulations of the neuroprotective NAP fragment of activity-dependent neuroprotective protein, for cognitive disorders.

Hugo, Geerts

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Article . 2008

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AL-108 and AL-208, formulations of the neuroprotective NAP fragment of activity-dependent neuroprotective protein, for cognitive disorders.

descriptionPublicationkeyboard_double_arrow_right Article 03 Oct 2008 English Journal:Current opinion in investigational drugs (London, England : 2000), volume 9 (issn: 1472-4472,

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Authors: Hugo, Geerts;

pmid: 18600585

AL-108 and AL-208, formulations of the neuroprotective NAP fragment of activity-dependent neuroprotective protein, for cognitive disorders.

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Abstract

Allon Therapeutics Inc is developing AL-108, an intranasally administered, eight-amino-acid peptide fragment (known as NAP) of activity-dependent neuroprotective protein, and AL-208, an intravenous formulation of NAP. AL-108 is undergoing phase II trials for cognitive impairment in Alzheimer's disease and schizophrenia. AL-108 is also being investigated as a neuroprotective agent, including for the treatment of Parkinson's disease and ocular disease. AL-208 is undergoing phase II clinical trials for the treatment of cognitive disorder and phase I clinical trials for ocular disease and cognitive deficits associated with coronary artery bypass graft or ischemia.

Keywords

Clinical Trials as Topic, Contraindications, Drug Evaluation, Preclinical, Patents as Topic, Structure-Activity Relationship, Neuroprotective Agents, Schizophrenia, Animals, Humans, Cognition Disorders, Oligopeptides

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