[Chronotropic activity of semax].

E B, Arushanian; A V, Popov

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Экспериментальная и ...arrow_drop_down

Экспериментальная и клиническая фармакология

Article . 2008

Data sources: Europe PubMed Central

[Chronotropic activity of semax].

descriptionPublicationkeyboard_double_arrow_right Article 25 Jul 2008 Russian Journal:Eksperimental'naia i klinicheskaia farmakologiia, volume 71 (issn: 0869-2092,

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Authors: E B, Arushanian; A V, Popov;

pmid: 18488900

[Chronotropic activity of semax].

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Abstract

The chronic administration of nootropic drug Semax, a peptide analog of ACTH (4-10), normalized the circadian locomotor rhythm in rats (with an increase in its amplitude, a shift in the acrophase, and a change of the spectral characteristics) and reduced the integral chronobiological index. It is suggested that the rhythm-synchronizing chronotropic activity may be a part of the specific effect of this cognitive enhancer.

Keywords

Male, Adrenocorticotropic Hormone, Animals, Motor Activity, Nootropic Agents, Peptide Fragments, Circadian Rhythm, Rats

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