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[Non-small-cell lung cancer].

Authors: Hirotoshi, Akita; Ichiro, Kinoshita;

[Non-small-cell lung cancer].

Abstract

Molecular targeted therapy in combination with chemotherapy or thoracic radiotherapy has been studied in clinical trials. Gefitinib or erlotinib in combination with standard chemotherapy did not improve efficacy on survival over standard chemotherapy alone in chemotherapy-naive patients with advanced NSCLC. On the other hand, bevacizumab in combination with standard chemotherapy improved survival in chemotherapy-naive patients with advanced NSCLC, excluding squamous cell carcinoma. Multi-target tyrosine kinase inhibitors in combination with standard chemotherapy, and anti-EGFR antibodies and EGFR tyrosine kinase inhibitors in combination with thoracic radiotherapy, are under clinical trials.

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Keywords

Lung Neoplasms, Antibodies, Monoclonal, Antineoplastic Agents, Gefitinib, Protein-Tyrosine Kinases, Antibodies, Monoclonal, Humanized, Combined Modality Therapy, Bevacizumab, ErbB Receptors, Erlotinib Hydrochloride, Carcinoma, Non-Small-Cell Lung, Quinazolines, Humans, Protein Kinase Inhibitors

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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