[Mannan-binding lectin and MBL-associated serine protease-2].
Copyright policy )[Mannan-binding lectin and MBL-associated serine protease-2].
In Denmark approximately 3,600 patients are diagnosed with colorectal cancer (CRC) every year. 75-80% of patients may undergo intended curative resection, but the disease recurs in about 40% within five years and the prognosis is poor. Hence, there is a need for biological markers that could be used for detection, evaluation of prognosis, therapy selection and monitoring. The serum proteins of the innate immune system mannan-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are novel biomarkers under validation in CRC. Low preoperative MBL levels are predictive of pneumonia which subsequently is associated with poor survival. High MASP-2 levels predict recurrence and poor survival.
- University of Copenhagen Denmark
- University of Copenhagen Denmark
- Hvidovre Hospital Denmark
Postoperative Complications, Mannose-Binding Protein-Associated Serine Proteases, Biomarkers, Tumor, Humans, Pneumonia, Neoplasm Recurrence, Local, Colorectal Neoplasms, Prognosis, Mannose-Binding Lectin
Postoperative Complications, Mannose-Binding Protein-Associated Serine Proteases, Biomarkers, Tumor, Humans, Pneumonia, Neoplasm Recurrence, Local, Colorectal Neoplasms, Prognosis, Mannose-Binding Lectin
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