Cancer survivors who have received cardiotoxic chemotherapy or mediastinal radiation have an increased risk of developing cardiovascular late effects. Cardiac functioning should be evaluated during follow-up exams based on the patient's risk factors, cardiac symptoms, and type of cancer treatment received. Signs and symptoms indicative of cardiovascular late effects include dyspnea, fatigue, tachycardia, nonproductive cough, neck vein distention, coarse breath sounds, and pedal edema.