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[Studies on absorption kinetics of paeonol and paeonol-beta-CD in rat's intestines].

descriptionPublicationkeyboard_double_arrow_right Article 21 Apr 2009Journal:Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, volume 33 (issn: 1001-5302, Copyright policy )
Authors: Rong-Feng, Hu; Cheng-Wu, Fang; Ai-Feng, Zou; Kang-Kang, Mei; Ji-Hui, Tang; Ling-Ling, Han;

pmid: 18338616

[Studies on absorption kinetics of paeonol and paeonol-beta-CD in rat's intestines].

Abstract

To explore the absorption mechanism of paeonol-beta-CD from various intestinal segments and offer biopharmaceutics data for paeonol new dosage form. The absorption kinetics and permeability rate consatants were investigated by the in situ perfusing method in rats. The absorption of the drug conforms to the firt-order kinetics and passive transport mechanism . The results indicate that paeonol-beta-CD absorption mechanism wasn't change.

Keywords

Male, Rats, Sprague-Dawley, Kinetics, Intestinal Absorption, Acetophenones, Animals, Intestinal Mucosa, Rats

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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