In vitro antiviral activity of plant extracts on goatpox virus replication.

V, Bhanuprakash; M, Hosamani; V, Balamurugan; P, Gandhale; Ram, Naresh; D, Swarup; R K, Singh

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Indian Journal of Ex...arrow_drop_down

Indian Journal of Experimental Biology

Article . 2008

Data sources: Europe PubMed Central

In vitro antiviral activity of plant extracts on goatpox virus replication.

descriptionPublicationkeyboard_double_arrow_right Article 22 Apr 2008 English Journal:Indian journal of experimental biology, volume 46 (issn: 0019-5189,

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Authors: V, Bhanuprakash; M, Hosamani; V, Balamurugan; P, Gandhale; Ram, Naresh; D, Swarup; R K, Singh;

pmid: 18335810

In vitro antiviral activity of plant extracts on goatpox virus replication.

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Abstract

Four plants having known medicinal properties were screened for inhibition of goatpox virus (GTPV) replication in vitro. Of the 4 plants, extract of Acacia arabica (Babul) and Eugenia jambolana (Jamun) leaves had inhibition (%) 99.70 and 99.92 at their maximum non toxic concentrations, 99.93 +/- 0.38 and 1999.73 +/- 0.50 microg/ml, respectively in all cytopathic effect (CPE) inhibition assays. Inhibition of GTPV virus replication was further confirmed by PCR and SYBR Green based quantitative real-time QPCR assays specific for GTPV. Results indicated that the extract of Acacia arabica and Eugenia jambolana leaves inhibited GTPV replication in vitro.

Related Organizations

Indian Veterinary Research Institute
India

Keywords

Plant Extracts, Syzygium, Acacia, Poxviridae Infections, In Vitro Techniques, Virus Replication, Antiviral Agents, Plant Leaves, Cytopathogenic Effect, Viral, Chlorocebus aethiops, Animals, Vero Cells, Capripoxvirus

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