In experiments performed on rats with hypothyrosis, the blood serum indexes (the level of triodthyronine, thyroxin, thyrothropic hormone of adenohypophysis, the level of cholesterol, triglycerides, nitric oxide) and the level of iodine excretion with urine before and after correction of iodine deficiency by "Iodide-100" drug has been studied. It has been revealed that hypothyrosis has negative influence on lipid metabolism indexes and is accompanied by decrease in nitric oxide level in blood serum. This could lead to destabilization of structure and functions of cells of different tissues of the organism. Administration of the drug "Iodide-100", leads to stabilization of hormonal and lipid states and nitric oxide level in blood serum increases.