[Expression of vascular endothelial growth factor, vascular endothelial growth factor receptor-3 and nm23-H1 in oral squamous cell carcinoma].
Copyright policy )[Expression of vascular endothelial growth factor, vascular endothelial growth factor receptor-3 and nm23-H1 in oral squamous cell carcinoma].
To explore the role of vascular endothelial growth factor C (VEGF-C), VEGFR-3 and nm23-H(1) in lymphatic metastasis of oral squamous cell carcinoma (OSCC).The expression of VEGF-C, VEGFR-3 and nm23-H(1) were examined by immunohistochemical SP method. The lymphatic vessels density (LVD) in tumors was counted and analyzed with clinicopathologic parameters.VEGF-C, LVD and nm23-H(1) expressions were significantly different between OSCC and benign and precancerous lesions (P < 0.05). VEGF-C was correlated with lymph node metastasis and LVD (P < 0.01). nm23-H(1) was related to clinical stage, histological grade and lymphatic metastasis (P < 0.05).The high expressions of VEGF-C/VEGFR-3 and inactivation of nm23-H(1) may play an important role in lymphatic metastasis in OSCC.
- First Affiliated Hospital of Bengbu Medical College China (People's Republic of)
Male, Lymphatic Metastasis, Vascular Endothelial Growth Factor C, Carcinoma, Squamous Cell, Humans, Female, Mouth Neoplasms, NM23 Nucleoside Diphosphate Kinases, Vascular Endothelial Growth Factor Receptor-3
Male, Lymphatic Metastasis, Vascular Endothelial Growth Factor C, Carcinoma, Squamous Cell, Humans, Female, Mouth Neoplasms, NM23 Nucleoside Diphosphate Kinases, Vascular Endothelial Growth Factor Receptor-3
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