Geographic vicinity, common economy and connections between Kama and Vyatka river basins require systemic opisthorchiasis studies in these Ural areas. Literary data show that the situation with opisthorchiasis on the Kama River is mainly studied in Komi-Permiak Autonomous Okrug and is unclear in the upper Kama, in Kirovsk Province. Additional data have been obtained and opisthorchiasis was for the first time found in the population, cats and mollusks in the upper Kama, in Kirovsk Province. Opisthorchiasis foci were for the first time discovered on the Vyatka River. The level of cat and fish invasion in the upper Kama was higher than on the Vyatka River, which might be accounted for by ethnic peculiarities of the population on the Kama River.