A stable isotope dilution mass spectrometric assay for the major urinary metabolite of PGD2.
Copyright policy )A stable isotope dilution mass spectrometric assay for the major urinary metabolite of PGD2.
1. A sensitive and specific negative ion chemical ionization mass spectrometric assay for the major urinary metabolite of PGD2 has been developed employing a chemically synthesized [18(0)4]-labelled internal standard. 2. The finding that increased urinary excretion of this metabolite occurs in a number of clinical situations suggests that the assay may prove to be a valuable tool to explore the role of PGD2 in the pathophysiology of human disease.
- Vanderbilt University United States
Prostaglandin D2, Prostaglandins D, Hypercholesterolemia, Indicator Dilution Techniques, Niacin, Asthma, Mass Spectrometry, Hydroxyprostaglandin Dehydrogenases, Humans, Bronchoalveolar Lavage Fluid, Mastocytosis, Histamine
Prostaglandin D2, Prostaglandins D, Hypercholesterolemia, Indicator Dilution Techniques, Niacin, Asthma, Mass Spectrometry, Hydroxyprostaglandin Dehydrogenases, Humans, Bronchoalveolar Lavage Fluid, Mastocytosis, Histamine
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