Cyclic beta-peptoids.
Copyright policy )Cyclic beta-peptoids.
The first synthesis of functionalized beta-peptoid macrocycles is reported. X-ray crystallographic structure of tetramer 9 reveals a C2-symmetrical derivative with unexpected all-cis-amide bonds and spatial disposition of the appendages toward the two opposite faces of the ring. Quantum calculations suggest that 9 is locked in this layout. These macrocycles constitute novel promising templates for multimeric ligation of biologically active ligands. The concept was exemplified by chemical decoration of tetramer 9 via "click" reactions.
Models, Molecular, Peptoids, Cyclization, Protein Conformation, Stereoisomerism, Crystallography, X-Ray, Peptides, Cyclic
Models, Molecular, Peptoids, Cyclization, Protein Conformation, Stereoisomerism, Crystallography, X-Ray, Peptides, Cyclic
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