Pathogenesis of Machupo virus infection in primates.
Copyright policy )Pathogenesis of Machupo virus infection in primates.
Experimental Machupo virus infection of rhesus and cynomolgus monkeys produced a severe illness consisting of an initial clinical phase and a later neurological phase. Cumulative mortality during the two phases was 80% and 95% respectively. Attempts to alter the pathogenesis with decomplementation or immunosuppression resulted in earlier deaths of the monkeys.
Immunosuppression Therapy, Hemorrhagic Fevers, Viral, Monkey Diseases, Complement System Proteins, Haplorhini, Macaca mulatta, Hemorrhagic Fever, American, Disease Models, Animal, Macaca fascicularis, Animals, Arenaviruses, New World
Immunosuppression Therapy, Hemorrhagic Fevers, Viral, Monkey Diseases, Complement System Proteins, Haplorhini, Macaca mulatta, Hemorrhagic Fever, American, Disease Models, Animal, Macaca fascicularis, Animals, Arenaviruses, New World
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