COX1 and COX2 polymorphisms and gastric cancer risk in a Polish population.
Copyright policy )COX1 and COX2 polymorphisms and gastric cancer risk in a Polish population.
Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied.Genotypes of several variants in both COX1 (Ex7+31 C>A and Ex10-4 G>A) and COX2 (-765 G>C, Ex10+837 T>C, Ex10-90 C>T, IVS5-275 T>G, and IVS7+111 T>C) were identified by TaqMan assays in 305 gastric cancer cases and 427 age- and gender-matched controls in a high-risk Polish population. Odds ratios for gastric cancer and 95% confidence intervals from unconditional logistic regression models were used to evaluate relative risks.We found no statistically significant evidence that the polymorphisms tested in COX1 and COX2 are associated with gastric cancer risk.These results suggest that the polymorphisms examined in COX1 and COX2 do not affect the risk of gastric cancer.
- Northwestern University United States
- University of Milan Italy
Adult, Male, Middle Aged, Polymorphism, Single Nucleotide, Cyclooxygenase 2, Stomach Neoplasms, Case-Control Studies, Cyclooxygenase 1, Humans, Female, Genetic Predisposition to Disease, Poland, Aged
Adult, Male, Middle Aged, Polymorphism, Single Nucleotide, Cyclooxygenase 2, Stomach Neoplasms, Case-Control Studies, Cyclooxygenase 1, Humans, Female, Genetic Predisposition to Disease, Poland, Aged
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