[Effect of HMME-PDT on hyperplastic scar in rabbit ear model].

Hong, Cai; Ying, Gu; Jing, Zeng; Shao-ran, Li; Ying, Wang; Dong-wen, Shi; Lu-yong, Zhang

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Article . 2010

Data sources: Europe PubMed Central

[Effect of HMME-PDT on hyperplastic scar in rabbit ear model].

descriptionPublicationkeyboard_double_arrow_right Article 11 Mar 2010Journal:Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery, volume 23 (issn: 1009-4598,

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Authors: Hong, Cai; Ying, Gu; Jing, Zeng; Shao-ran, Li; Ying, Wang; Dong-wen, Shi; Lu-yong, Zhang;

pmid: 18161362

[Effect of HMME-PDT on hyperplastic scar in rabbit ear model].

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Abstract

To investigate the effect of HMME-PDT (Hematoporphyrin Monomethyl Ether-Photodynamic therapy) on Hyperplastic scar in the rabbit ear.The acute model of dermal Hyperplastic scar in the rabbit ear was established. 24 scars were randomly divided into 2 groups: the experimental group (n = 12) received HMME-PDT treatment, and the controlled group (n = 12) received no special treatment. Specimens were harvested from scars on postoperative 28 day. Scar hyper plasty and collagen fibers were observed by haematoxylin-eosin staining and Van-Gieson staining respectively. The microvessel density was calculated under microscope.Compared with the controlled group, HMME-PDT treatment in the experimental group reduced scar formation, decreased the microvessel density and prevented excess collagen deposition at the wound site.HMME-PDT may play a role in inhibiting hyperplastic scar in rabbit ear.

Related Organizations

Chinese PLA General Hospital
China (People's Republic of)

Keywords

Male, Hematoporphyrins, Cicatrix, Hypertrophic, Photochemotherapy, Animals, Ear, Female, Rabbits

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