Bursts of focused ultrasound energy a billion times more intense than diagnostic ultrasound have become a non-invasive option for tumor ablation, from prostate cancer to uterine fibroid, during the last decade. Despite this progress, many issues still need to be addressed. First, for brain targeting, the correction of distortions induced by the skull remains today a technological achievement that still needs to be validated clinically. Secondly, the problem of motion artifacts for abdominal treatments becomes today an important research topic. For all these issues, the potential of new ultrasonic therapy devices able to work both in Transmit and Receive modes will be emphasized and clinical results on monkeys and pigs will be presented.