Ejaculation dysfunction is one of the most common sexual disorders and premature ejaculation is considered the most frequent self-reported male sexual dysfunction. Both central and peripheral neural system is involved in the ejaculatory process. It is centrally mediated by the serotonergic and dopaminergic system. The epidemiology of premature ejaculation (PE) is limited by the lack of consensus definition of lifelong PE and a failure to distinguish lifelong and acquired PE. The diagnosis is based on patient self-report, questionnaires, clinical history and examination findings alone. The treatment uses pharmacologic alone or associated with psychogenic support. Different psychotherapeutic approaches to PE have been described but their efficacies have not been evaluated. A better understanding of PE is undoubtedly necessary to obtain the most efficient results.