The prolonged presence of superficial mucosal sutures or perineal sutures may cause irritation or discomfort and increase the risk of bacterial infections. Although absorbable sutures are commonly used in mucosal areas, many sutures have a prolonged half-life and might still require removal when used superficially. We highlight the use of irradiated polyglactin 910 (IRPG) for closure of mucosal defects and areas where short-term wound support is required. We used IRPG in 50 patients for closure of defects on the lips, oral mucosa, and penis. In all cases, IRPG sutures provided appropriate tensile strength with minimal inflammation, suppuration, or irritation. IRPG resulted in low inflammatory response, rapid degeneration, soft feel, and easy workabil-ity, making it an ideal suture option for closure of mucosal defects and areas where short-term wound support is desired.