An analysis is made on the clinical symptoms of 72 women with diagnosis of atypical hyperplasia established morphologically. The clinical data are manifested in accordance with the periods of the woman: reproductive climacteric and menopausal. Dysfunctional uterine bleedings, combined with endocrine-metabolic disturbances, predominate. A substantial connection between the atypical hyperplasia and the frequency of patients with myoma of the uterus is established as well as the closeness between the clinical picture of atypical characteristic and endometrial adenocarcinoma. Patients with atypical characteristics are formed as risk group for occurrence of endometrial carcinoma. It is necessary to know risk factors for occurrence of endometrial pre-carcinoma as well as indispensable condition for organization of more effective prophylaxis.