The revised Norwegian biotechnology law implies restrictive use of preimplantation genetic diagnostics--a highly specialised procedure, which is still in an early phase of development.The paper is based on more than 10 years of clinical experience in preimplantation genetic diagnostics and on literature retrieved through PubMed/Medline.According to the biotechnology law, preimplantation genetic diagnostics can only be carried out when strict medical indications are present. Genetic counselling and a fertility work-up are compulsory for couples who wish to receive preimplantation genetic diagnostics.Few disorders have an indication for preimplantation genetic diagnostics. It will therefore take time to build up adequate national expertise. For couples with a known risk of serious hereditary disease, preimplantation genetic diagnosis is useful in achieving an uncomplicated pregnancy and a healthy child.