Until recently, living kidney donations between donors and recipients of different blood groups were contraindicated. Since 2004, blood group incompatible kidney transplantations have been performed in Germany. Through the use of the anti-CD20 antibody rituximab and a highly selective immunoadsorption treatment, the recipient's antibodies against the foreign blood group are removed before the transplantation to minimize the risk of an antibody-mediated acute rejection reaction after the transplantation.