[Phenytoin and phenytoin derivatives for local administration].

A well known side effect of the long-term therapy with phenytoin is gum hyperplasia. 1-Acyl compounds and esters of the p-hydroxymetabolite with aliphatic and aromatic carboxylic acids were synthesized as potential prodrugs for therapeutic use if the neoformation of connective tissue is intended. The compounds were characterized by there physico-chemical constants and the absorption was proofed by a buccal test.

Related Organizations

Martin Luther University Halle-Wittenberg
Germany

Keywords

Solubility, Hydrolysis, Phenytoin, Administration, Buccal, Prodrugs, Absorption

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average