Intrahepatic cholestasis has become a very important aspect of liver disease. The author, in the light of electron microscopy and the theory of filtration-reabsorption of bile secretion proposes that the disease may be explained by obstructions situated at various levels of the inter-cellular spaces of the liver. This obstruction is functional at first, but is maintained by a duodeno-hepatic inhibitory reflex, the existence of which has been demonstrated by the author. In the light of facts and documents presented here, one may see that from Monneret until now, various authors have come very close to the true mechanism of this type of jaundice, each discovering some aspect of the truth.