[Expression of Fas, Fas ligand, Fas-associated death domain protein, caspase 8 and mutant P53 protein in esophageal squamous cell carcinoma].
Copyright policy )[Expression of Fas, Fas ligand, Fas-associated death domain protein, caspase 8 and mutant P53 protein in esophageal squamous cell carcinoma].
To investigate the expression of five apoptosis-related proteins, Fas, Fas ligand (FasL), Fas-associated death domain protein (FADD), caspase 8, and mutant p53, in human esophageal squamous cell carcinoma (ESCC) tissue, and analyze the association of these proteins with ESCC malignant progression.116 ESCC specimens obtained during operation. Tissue microarray composed of the 116 specimens of cancerous tissues and corresponding paracancerous normal epithelium tissues was constructed. The expression of Fas, FasL, FADD, caspase 8, and mutant p53 was detected in the ESCC tissues and paracancerous normal epithelium tissues and analysis was conducted for the correlation between the expression of these proteins and the pathoclinical features and prognosis. involvement, differentiated grade, pTNM stages and disease-free survival.The positive rate of Fas in the ESCC tissues was 41.4%, significantly lower than that in the normal squamous epithelium was 95.7%, P 0.05).The apoptosis-related markers, such as Fas, FasL, FADD, caspase 8, and mutant p53 protein may play important roles in the development and progression of ESCC, and FADD can be used as a marker to predict the advance and prognosis of ESCC.
- Chinese Academy of Medical Sciences & Peking Union Medical College China (People's Republic of)
Adult, Male, Caspase 8, Fas Ligand Protein, Esophageal Neoplasms, Fas-Associated Death Domain Protein, Middle Aged, Immunohistochemistry, Disease-Free Survival, Tissue Array Analysis, Biomarkers, Tumor, Carcinoma, Squamous Cell, Disease Progression, Humans, Female, Mutant Proteins, fas Receptor, Tumor Suppressor Protein p53, Aged, Follow-Up Studies
Adult, Male, Caspase 8, Fas Ligand Protein, Esophageal Neoplasms, Fas-Associated Death Domain Protein, Middle Aged, Immunohistochemistry, Disease-Free Survival, Tissue Array Analysis, Biomarkers, Tumor, Carcinoma, Squamous Cell, Disease Progression, Humans, Female, Mutant Proteins, fas Receptor, Tumor Suppressor Protein p53, Aged, Follow-Up Studies
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