The conjunctival provocation test (CPT) is a human model of ocular allergy that has been used to study the ocular response to allergenic stimuli and to evaluate antiallergic therapy. Considerable useful information has been gained on the ocular allergic response and drug efficacy using the conjunctival provocation test and naturally occurring seasonal allergic conjunctivitis. The safety and the efficacy of these CPTs has resulted in many authors using this tool in the etiologic diagnosis of allergic conjunctivitis. This article summarizes the possibilities of these CPTs as a tool for the study, evaluation, diagnosis, and therapeutic follow-up of allergic conjunctivitis.