[Osteoclast differentiation and activation].
Copyright policy )[Osteoclast differentiation and activation].
In autoimmune arthritis, activation of T cells induces bone destruction through receptor activator of NF-kappaB ligand (RANKL) . Recent study revealed interleukin-17 (IL-17) -producing helper T cell subset (Th17) , but not IFN-gamma-producing Th1, to be responsible for bone destruction. Here we summarize the current understanding of osteoclast differentiation and activation in the context of osteoimmunology.
Interleukin-17, RANK Ligand, Osteoclasts, Cell Differentiation, T-Lymphocytes, Helper-Inducer, Lymphocyte Activation, Bone and Bones, Arthritis, Rheumatoid, T-Lymphocyte Subsets, Animals, Humans, Signal Transduction
Interleukin-17, RANK Ligand, Osteoclasts, Cell Differentiation, T-Lymphocytes, Helper-Inducer, Lymphocyte Activation, Bone and Bones, Arthritis, Rheumatoid, T-Lymphocyte Subsets, Animals, Humans, Signal Transduction
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