
The aim of the work was to assess vascular endothelial growth factor VEGF-C and vascular endothelial growth factor VEGF-D expression in ovarian carcinomas.Clinical records and preserved specimens from 80 patients with ovarian cacinoma who underwent treatment at Lower Silesia Centre of Oncology were examined consecutively.Most of analysed patients (n=53) had serous adenocarcinomas at III or IV FIGO stage. The median VEGF-C expression analysed semiquantitively using immunohistochemistry method was 3.84, and in 5% of cases expression of marker was not found. Also median VEGF-D expression was 3.71, and reactivity of this cytokine was not found in 16.25% of cases. There was strong correlation between expression of VEGF-C and VEGF-D. Conversely, there was no significant correlation between VEGF-C and VEGF-D expression and clinicopathological features of ovarian carcinoma. Univariate analysis demonstrated that high expression of cytokines wasn't associated with worse survival rate.This incresistence indicated that studies on angiogenesis in ovarian carcinomas should be continued.
Adult, Ovarian Neoplasms, Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D, Middle Aged, Immunohistochemistry, Survival Analysis, Biomarkers, Tumor, Humans, Female, Poland, Neoplasm Staging, Retrospective Studies
Adult, Ovarian Neoplasms, Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D, Middle Aged, Immunohistochemistry, Survival Analysis, Biomarkers, Tumor, Humans, Female, Poland, Neoplasm Staging, Retrospective Studies
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