Studies on the endocrine effects of the contents of Cimicifuga racemosa:.

Endocrine activity can be demonstrated for components of the rhizome of CIMICIFUGA RACEMOSA using ovariectomized rats as experimental model. A selective reduction of the serum concentration of the pituitary luteinizing hormone (LH) takes place upon application of an extract. The active principle can be concentrated by extraction with dichloromethane. Enzymatic hydrolysis of glucosides leads to a significant loss of endocrine activity in the experimental model system of the ovariectomized rat.

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