[The action of decorin in anti-fibrosis and anti-cancer].

Weifeng, Ma; Yi, Tan; Shaohui, Cai; Hongyuan, Chen; Jun, Du; Shaoxi, Cai

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Article . 2009

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[The action of decorin in anti-fibrosis and anti-cancer].

descriptionPublicationkeyboard_double_arrow_right Article 21 May 2009Journal:Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, volume 24 (issn: 1001-5515,

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Authors: Weifeng, Ma; Yi, Tan; Shaohui, Cai; Hongyuan, Chen; Jun, Du; Shaoxi, Cai;

pmid: 17333927

[The action of decorin in anti-fibrosis and anti-cancer].

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Abstract

Decorin (DCN) is a member of the small leucine-rich proteoglycan gene family. Many studies indicated that DCN inhibited fibrosis and scar-formation by neutralization of TGF-P and interfering the binding of TGF-beta with its receptor, which induced ectopic deposition of extracellular matrix. Additionally, DCN can prevent the proliferation and metastasis of tumor cells by activating EGFR/MAPK/p21 signal pathway and inhibiting the cell proliferation pathway mediated by EGF-EGFR. It is suggested that the recombinant DCN had potential pharmaceutical potency in treatment of chronic fibrosis and neoplasm for its critical biological activities and low immunogenicity.

Related Organizations

Chongqing University
China (People's Republic of)

Keywords

ErbB Receptors, Transforming Growth Factor beta1, Extracellular Matrix Proteins, Animals, Humans, Antineoplastic Agents, Proteoglycans, Decorin, Fibrosis, Recombinant Proteins

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