The article presents a short review on the role of microelements in hemapoesis, main mechanisms of their influence on hemopoiesis and erythrogenesis. The content of Fe, Cu, Mr, Zn and Co in washed erythrocytes of peripheral venous blood of primary and regular donors was studied by the help of atomic absorption spectroscopy technique. It was established that in regular donors their blood have a changed level of Fe and Mr in erythrocytes but levels of Cu, Co and Zn remained unchanged. The author drew a conclusion that detected changes necessitate the development of a complex of measures on the prophylaxis of deficiencies in these metals in regular donors.