[Progressive multifocal leukoencephalopathy (PML) in AIDS: morphological and topographical characteristics].

K, Kuchelmeister; F, Gullotta; M, Bergmann; G, Angeli; T, Masini

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Article . 1992

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[Progressive multifocal leukoencephalopathy (PML) in AIDS: morphological and topographical characteristics].

descriptionPublicationkeyboard_double_arrow_right Article 23 Apr 1992 German Journal:Verhandlungen der Deutschen Gesellschaft fur Pathologie, volume 75 (issn: 0070-4113,

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Authors: K, Kuchelmeister; F, Gullotta; M, Bergmann; G, Angeli; T, Masini;

pmid: 1724829

[Progressive multifocal leukoencephalopathy (PML) in AIDS: morphological and topographical characteristics].

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Abstract

15 autopsy cases of PML in AIDS are presented. Frequent findings were: Very large, confluent PML-lesions (7 cases), lesions with prominent necrotic features (10 cases) and with marked perivascular mononuclear infiltrates (6 cases). In 9 cases additional PML-foci were seen in the cerebellum and/or the brain stem, and in 1 case there was even an exclusive involvement of those structures. Such characteristics regarding severity and topography of PML in AIDS, may be due to additional toxic factors. In 7 cases HIV-encephalopathy with multinucleated macrophages was present.

Related Organizations

University of Münster
Germany

Keywords

Adult, Male, Acquired Immunodeficiency Syndrome, Leukoencephalopathy, Progressive Multifocal, Brain, Cerebellum, Humans, Female, Autopsy, Brain Stem

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