[New drugs; nitisinone].

A F, Cohen; H, van Bronswijk

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Article . 2007

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[New drugs; nitisinone].

descriptionPublicationkeyboard_double_arrow_right Article 09 Jan 2007 Dutch; Flemish Journal:Nederlands tijdschrift voor geneeskunde, volume 150 (issn: 0028-2162,

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Authors: A F, Cohen; H, van Bronswijk;

pmid: 17152330

[New drugs; nitisinone].

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Abstract

Nitisinone is an inhibitor of 4-hydroxyphenyl-pyruvate dioxygenase (4HPPD). Its rare area of use is hereditary tyrosinaemia, a life-threatening disease in which the last step in the catabolism of tyrosine cannot be taken due to the absence of an enzyme. The inhibition of 4HPPD, an enzyme that is active early in the catabolic cascade, prevents the accumulation of toxic metabolites of tyrosine.

Related Organizations

Centre for Human Drug Research
Netherlands

Keywords

Cyclohexanones, Tyrosinemias, Nitrobenzoates, Humans, Tyrosine, Enzyme Inhibitors

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